Twenty-one people were killed when Russian artillery destroyed a school and community center in Merefa, near the northeastern city of Kharkiv, officials said.
Merefa Mayor Veniamin Sitov said the attack happened just before dawn on Thursday.
The Kharkiv region has come under heavy shelling as pinned down Russian forces attempt to advance in the area.
In the town of Chernihiv, northeast of kyiv, Ukrainian emergency services said a hostel had been bombed, killing a mother, father and three of their children, including 3-year-old twins.
Russian forces in Ukraine are blowing up towns and killing civilians but making no further progress on the ground, Western nations said on Thursday, as a war Moscow had hoped to win in days entered its fourth week.
Viacheslav Chaus, governor of Chernihiv, said 53 civilians had been killed there in the past 24 hours. The toll could not be independently verified.
In the capital kyiv, a building in the Darnytsky district was badly damaged by what authorities said was debris from a downed missile early in the morning.
As residents cleaned glass and carried away bags of possessions, a man knelt crying beside the body of a woman who lay near a door, covered in a bloody sheet.
The New York Times reported that the Pentagon estimates that more than 7,000 Russian soldiers have been killed since the war began three weeks ago, more than all American soldiers killed in 20 years of war in Iraq and Afghanistan. reunited.
British military intelligence said in an update on Thursday that the invasion was “largely blocked on all fronts” and that Russian forces were suffering heavy casualties from firm and well-coordinated Ukrainian resistance.
Russia attacked Ukraine from four directions, sending two massive columns towards kyiv from the northwest and northeast, pushing from the east near the second-largest city of Kharkiv and spreading south from Crimea .
kyiv’s northeastern and northwestern suburbs were reduced to rubble by heavy fighting, but the capital itself held firm, under a curfew and subject to deadly nighttime rocket attacks.
Elsewhere, foreign ministers from major Group of Seven economies are calling on Russia to comply with the International Court of Justice’s order to halt its attack on Ukraine and withdraw its military forces.
In a joint statement, senior G-7 diplomats condemned what they described as “indiscriminate attacks on civilians” by Russian forces, including the siege of Mariupol and other cities.
Meanwhile, a UN agency has warned that the conflict in Ukraine is likely to hamper access to food and fuel for many of the world’s most vulnerable people.
A report by the United Nations Conference on Trade and Development notes that Russia accounted for almost a third of wheat imports for Africa, or $3.7 billion, in 2018-2020, while 12 %, worth $1.4 billion, came from Ukraine.
The report says early assessments point to a “substantial reduction” in access to food and fuel despite efforts to prevent the disruption of supplies of staples such as wheat.
Meanwhile, rising costs of shipping and grain and other staples are pushing prices up, hitting the poorest people the hardest, the report said.
The report says that up to 25 African countries, especially the least developed economies, depend on wheat imports from Russia and Ukraine.
The lack of spare capacity in Africa limits the ability of these countries to make up for any loss of supply, while soaring fertilizer costs will place an additional burden on farmers.